TDM TorinoTDM TorinoClinical Pharmacology and Pharmacogenetics

University of Turin · ASL Città di Torino

Drug measurement for personalised therapy

Since 2002 the Laboratory of Clinical Pharmacology and Pharmacogenetics at Amedeo di Savoia Hospital has provided therapeutic drug monitoring, pharmacogenetics and LC-MS/MS bioanalysis for clinicians, clinical trials, the pharmaceutical industry and pharmacies.

Home of the Specialisation School in Clinical Pharmacology and Toxicology · University of Turin
How to send samplesFind a drug
For clinicians

Request TDM for your patients: sampling and shipping instructions, request forms, drugs measured and turnaround times.

Anti-infectivesAntiretroviralsAntipsychoticsPharmacogeneticsShipping instructions → For industry, pharmacies and research

Bioanalytical support for Phase 1 and 2 clinical trials, LC-MS/MS method development and validation, and bioequivalence. For pharmacies: potency testing of cannabis-based galenic preparations.

Phase 1 studiesMethod developmentBioequivalenceCannabinoids · pharmaciesGo to industry services →
88drugs measured routinely
≤ 5 daysturnaround for most drugs
ISO 9001 · 13485certified · aligned with ISO 15189
Phase 1laboratory for Phase 1 clinical trials (AIFA)

For clinicians · Sample shipping

How to send samples

Please follow every step carefully: samples collected or shipped incorrectly cannot be analysed. For pharmacogenetic tests see the dedicated page.

  1. 1

    Blood collection

    Collect one 7 mL Vacutainer LH tube, green cap (lithium heparin). Use 2 tubes if 2 or more drugs are to be measured.

  2. 2

    Centrifugation

    Within 15–20 minutes of collection, 1300 g for 10 minutes at 4 °C (about 2500–3000 rpm in standard serum centrifuges).

  3. 3

    Aliquots and labels

    Transfer at least 1 mL of plasma into 2 screw-cap cryovials for each drug. Label with patient surname or ID, sampling date and, for AUC points only, the sampling time (e.g. Rossi, 25/10/2026, T-0).

  4. 4

    Storage

    Freeze immediately at −20/−80 °C until shipping, without heat-inactivating any HIV virus.

Required documents

  • The sample request form, completed in full, one per sample/patient.
  • For Italian centres: the regional prescription (Piedmont) or an authorisation signed by your hospital's Medical Directorate, covering all drugs requested (exam code 90.20.8, Piedmont tariff, per assay). International senders: please contact us before shipping to agree on the order and invoicing.

Samples received without this documentation will not be analysed.

Shipping

Frozen plasma

  • Packages must arrive Tuesday, Wednesday or Thursday, 9:00–15:00 (CET), so they do not sit in the mail room over the weekend.
  • Aliquots sorted by patient in a suitable container, still frozen.
  • Express delivery (within 24 hours) on dry ice at controlled temperature, at the sender's expense.

DSSD at room temperature

  • Plasma (DPS) for TDM and blood (DBS) for pharmacogenetics on the Dried Sample Spots Device.
  • Envelope by ordinary mail or courier, prepared according to the instruction leaflet.
  • Should arrive as soon as possible, ideally within 24 hours.
DSSD instructions and eligible drugs (PDF) →

Shipping address

Attn. Mauro Sciandra and/or Antonio D'Avolio

Clinica Universitaria delle Malattie Infettive
Laboratorio di Farmacologia Clinica e Farmacogenetica
Padiglione Q, Ospedale Amedeo di Savoia
C.so Svizzera 164 – 10149 Torino, Italy

Notify us 1–2 days before shipping

Email info@tdm-torino.org. For any question: +39 011 439 3867.

Stability, storage and shipping of each drug (PDF) →

Sample request forms

Current versions. Fill in the form for the drug class and send it with the sample.

AntiretroviralsOPG01_5 Rev.2 · PDF Antibiotics and antifungalsOPG01_6 Rev.1 · PDF Other drugsOPG01_14 Rev.1 · PDF AntihypertensivesOPG01_19 Rev.1 ENG · PDF PharmacogeneticsOPG01_10 Rev.1 · PDF CannabinoidsOPG01_13 Rev.0 · PDF Full drug list 2026OPG01_8 · PDF
Other matricesWe also measure drugs in CSF, PBMCs, cell lysates, urine, bone and other matrices. Please contact the laboratory first (+39 011 439 3867) to agree on collection and storage.

Drug list

Find the drug you need

Routine service on plasma (lithium heparin, minimum 1 mL). Other drugs can be measured within scientific collaborations, by agreement with the laboratory.

For industry, pharmacies and research

A bioanalytical partner for your studies

We develop and validate methods for pharmaceutical companies, clinical trials and research projects, and offer pharmacies analytical testing of cannabis-based preparations, under a certified quality system.

Phase 1 and 2 clinical trials

Drug assays for pharmacokinetic studies, with sample handling under certified procedures. The only laboratory in Piedmont performing drug assays for Phase 1 studies.

Method development and validation

LC-MS/MS methods in plasma, PBMCs, urine and alternative matrices, including new molecules.

Bioequivalence and stability

Technical and scientific consultancy on bioequivalence and stability studies.

For pharmacies and industry

Cannabinoids

Potency testing of compounded cannabis preparations (e.g. oils) for pharmacies. Analysis of industrial hemp and derived products, including foods.

Sample request form (PDF) →
Request a quote Service standards (PDF, Italian)

Pharmacogenetics

The right drug for the right patient

Genotyping of polymorphisms relevant to drug response, including CYP2C19, CYP2D6 and CYP3A4/5, also from blood on DBS shipped at room temperature.

List of polymorphisms →

Training

Home of a Specialisation School

The laboratory hosts the University of Turin's Specialisation School in Clinical Pharmacology and Toxicology: residents carry out their hands-on training here in TDM, pharmacogenetics and bioanalysis.

Quality

A certified quality system

ISO 9001Certified, valid until 2029 ISO 13485Certified, valid until 2029
ISO 15189Laboratory aligned with the standard
Phase 1AIFA register of laboratories
Qualitypolicy (PDF, Italian)